Prof. Dr. med. Barbara Brotschi

Originalarbeiten

1. Comparison of carbon dioxide control during pressure controlled versus pressure regulated volume controlled ventilation in children (CoCO2): protocol for a pilot digital randomized controlled trial in a quaternary paediatric intensive care unit.
   BMJ Open
2. Redirection of care for neonates with hypoxic-ischemic encephalopathy receiving therapeutic hypothermia.
   Journal of Clinical Medicine
3. Elevated cerebral perfusion in neonatal encephalopathy is associated with neurodevelopmental impairments.
   Tuura RO, Kottke R, Brotschi B, Sabandal C, Hagmann C, Latal B.
4. Innovative air mattress for the prevention of pressure ulcers in neonates.
   Jucker TA, Annaheim S, Morlec E, Camenzind M, Schlüer AB, Brotschi B, Rossi RM.
   J Wound Care. 2024 Sep 2;33(9):652-658. doi: 10.12968/jowc.2024.0121.
5. Blood lactate levels during therapeutic hypothermia and neurodevelopmental outcome or death at 18 -24 months of age in neonates with moderate and severe hypoxic-ischemic encephalopathy.
   Boerger W, Mozun R, Frey B, Liamlahi R, Grass B, Brotschi B.
   Neonatology. 2024;121(6):693-702. doi: 10.1159/000538879.
6. «Parents’ experiences on therapeutic hypothermia for neonates with hypoxic-ischemic encephalopathy (HIE) – a single-center cross-sectional study».
   Grass B, Erlach M, Cippa G, Hagmann C, Brotschi B.
   Qual Manag Health Care. 2024 Apr-Jun 01;33(2):94-100. doi: 10.1097/QMH.0000000000000414.
7. Use of a novel pressure distribution system for severely ill neonates: a clinical pilot study carried out by the PREPICare consortium.
   Schlüer AB, Müller AY, Fromme NP, Camenzind M, Riener R, Rossi RM, Brotschi Aufdenblatten
   BB.BMC Pediatr. 2023 Nov 23;23(1):593. doi: 10.1186/s12887-023-04252-2.
8. «Increase in standardized management of neonates with hypoxic-ischemic encephalopathy since implementation of a patient register».
   André Birkenmaier, Adams M, Kleber M, Schwendener Scholl K, Rathke V, Hagmann C, *Brotschi B,*Grass B;
   Swiss National Asphyxia and Cooling Register.* shared last authorship. Ther Hypothermia Temp Manag. 2023 Feb 22. doi: 10.1089/ther.2022.0055. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36811496/
9. Technical feasibility of using auditory phase-targeted stimulation after pediatric severe traumatic brain injury in an intensive care setting.
   Albrecht JN, Jaramillo V, Huber R, Karlen W, Baumann CR, Brotschi B.
   BMC Pediatr. 2022 Oct 26;22(1):616. doi: 10.1186/s12887-022-03667-7. https://pubmed.ncbi.nlm.nih.gov/36289537/
10. Association of perinatal sentinel events, placental pathology and cerebral MRI in neonates with hypoxic-ischemic encephalopathy receiving therapeutic hypothermia.
    Hellwig L, Brada M, Held U, Hagmann C, Bode P, Frontzek K, Frey B, Brotschi B, Grass B.
    J Perinatol. 2022 Jul;42(7):885-891. doi: 10.1038/s41372-022-01356-y. https://pubmed.ncbi.nlm.nih.gov/35228682/
11. The SARS-CoV-2 Pandemic Impacts the Management of Swiss Pediatric Intensive Care Units.
    Soomann M, Wendel-Garcia PD, Kaufmann M, Grazioli S, Perez MH, Hilty MP, André MC, Brotschi B.
    Front Pediatr. 2022 Jan 28;10:761815. doi: 10.3389/fped.2022.761815. https://pubmed.ncbi.nlm.nih.gov/35155302/
12. Treatment of Catheter-Related Arterial Thrombosis in Children: A 15-Year Single- Center Experience.
    Crameri O, Brotschi B, Achini F, Rizzi M, Albisetti M.
    J Pediatr. 2021 Dec;239:182-186. doi: 10.1016/j.jpeds.2021.08.035. https://pubmed.ncbi.nlm.nih.gov/34450125/
13. Process variations between Swiss units treating neonates with hypoxic-ischemic encephalopathy and their effect on short-term outcome.
    Adams M, Brotschi B, Birkenmaier A, Schwendener K, Rathke V, Kleber M, Hagmann C; Swiss National Asphyxia and Cooling Register Group.
    J Perinatol. 2021 Dec;41(12):2804-2812. doi: 10.1038/s41372-021-01156-w. https://pubmed.ncbi.nlm.nih.gov/34290374/
14. Placental findings are not associated with neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy – an 11-year single-center experience.
    Benz LD, Bode PK, Brandt S, Grass B, Hagmann C, Liamlahi R, Frey B, Held U, Brotschi B.
    J Perinat Med. 2021 Oct 21;50(3):343-350. doi: 10.1515/jpm-2020-0583. https://pubmed.ncbi.nlm.nih.gov/34670032/
15. Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency.
    Vavassori S, Chou J, Faletti LE, Haunerdinger V, Opitz L, Joset P, Fraser CJ, Prader S, Gao X, Schuch LA, Wagner M, Hoefele J, Maccari ME, Zhu Y, Elakis G, Gabbett MT, Forstner M, Omran H, Kaiser T, Kessler C, Olbrich H, Frosk P, Almutairi A, Platt CD, Elkins M, Weeks S, Rubin T, Planas R, Marchetti T, Koovely D, Klämbt V, Soliman NA, von Hardenberg S, Klemann C, Baumann U, Lenz D, Klein-Franke A, Schwemmle M, Huber M, Sturm E, Hartleif S, Häffner K, Gimpel C, Brotschi B, Laube G, Güngör T, Buckley MF, Kottke R, Staufner C, Hildebrandt F, Reu-Hofer S, Moll S, Weber A, Kaur H, Ehl S, Hiller S, Geha R, Roscioli T, Griese M, Pachlopnik Schmid J.
    J Allergy Clin Immunol. 2021 Aug;148(2):381-393. doi: 10.1016/j.jaci.2021.03.045. https://pubmed.ncbi.nlm.nih.gov/33872655/
16. Centre-specific differences in short-term outcomes in neonates with hypoxic-ischaemic encephalopathy.
    Grass B, Brotschi B, Hagmann C, Birkenmaier A, Schwendener K, Adams M, Kleber M, Swiss National Asphyxia And Cooling Register.
    Swiss Med Wkly. 2021 Apr 5;151:w20489. doi: 10.4414/smw.2021.20489. https://pubmed.ncbi.nlm.nih.gov/33938562/
17. Association of perinatal risk factors with neurological outcome in neonates with hypoxic ischemic encephalopathy.
    Scheidegger S, Held U, Grass B, Latal B, Hagmann C, Brotschi B; National Asphyxia and Cooling Register Group.
    J Matern Fetal Neonatal Med. 2021 Apr;34(7):1020-1027. doi: 10.1080/14767058.2019.1623196. https://pubmed.ncbi.nlm.nih.gov/31117854/
18. Video Recordings to Analyze Preventable Management Errors in Pediatric Resuscitation Bay.
    Borns J, Ersch J, Dobrovoljac M, Staubli G, Brotschi B.
    Pediatr Emerg Care. 2020 Oct;36(10):e558-e563. doi: 10.1097/PEC.0000000000001403. https://pubmed.ncbi.nlm.nih.gov/29346233/
19. Risk Factors for Postprocedural Arterial Ischemic Stroke in Children With Cardiac Disease.
    Henzi BC, Brotschi B, Balmer C, Hennig B, Rimensberger P, Perez MH, Pfammatter JP, Beghetti M, Sekarski N, Datta AN, Fluss J, Faignart N, Hackenberg A, Regényi M, Steinlin M, Hug MI.
    Stroke. 2020 Sep;51(9):e242-e245. doi: 10.1161/STROKEAHA.120.029447. https://pubmed.ncbi.nlm.nih.gov/32811375/
20. Swiss newborn screening for severe T and B cell deficiency with a combined TREC/KREC assay – management recommendations.
    Trück J, Prader S, Natalucci G, Hagmann C, Brotschi B, Kelly J, Bassler D, Steindl K, Rauch A, Baumgartner M, Fingerhut R, Hauri-Hohl M, Güngör T, Pachlopnik Schmid J, Berger C, Reichenbach J.
    Swiss Med Wkly. 2020 Jun 24;150:w20254. doi: 10.4414/smw.2020.20254. https://pubmed.ncbi.nlm.nih.gov/32579701/
21. Abdominal compartment syndrome and decompressive laparotomy in children: a 9-year single-center experience.
    Di Natale A, Moehrlen U, Neeser HR, Zweifel N, Meuli M, Mauracher AA, Brotschi B, Tharakan S
    J.Pediatr Surg Int. 2020 Apr;36(4):513-521. doi: 10.1007/s00383-020-04632-0. https://pubmed.ncbi.nlm.nih.gov/32112129/
22. Short-term neurological improvement in neonates with hypoxic-ischemic encephalopathy predicts neurodevelopmental outcome at 18-24 months.
    Grass B, Scheidegger S, Latal B, Hagmann C, Held U, Brotschi B; National Asphyxia and Cooling Register Group;
    Follow-up Group J Perinat Med. 2020 Mar 26;48(3):296-303. doi: 10.1515/jpm-2019-0391. https://pubmed.ncbi.nlm.nih.gov/32069247/
23. Transthoracic intracardiac catheters in pediatric cardiac patients: A single-center experience.
    Beham K, Dave H, Kelly J, Frey B, Hug MI, Brotschi B.
    Paediatr Anaesth. 2017 Sep;27(9):918-926. doi: 10.1111/pan.13204. https://pubmed.ncbi.nlm.nih.gov/28707420/
24. Relationship between temperature variability and brain injury on magnetic resonance imaging in cooled newborn infants after perinatal asphyxia.
    Brotschi B, Gunny R, Rethmann C, Held U, Latal B, Hagmann C.
    J Perinatol. 2017 Sep;37(9):1032-1037. doi: 10.1038/jp.2017.96. https://pubmed.ncbi.nlm.nih.gov/28617423/
25. Postoperative Amplitude-Integrated Electroencephalography Predicts Four-Year Neurodevelopmental Outcome in Children with Complex Congenital Heart Disease.
    Latal B, Wohlrab G, Brotschi B, Beck I, Knirsch W, Bernet V.
    J Pediatr. 2016 Nov;178:55-60.e1. doi: 10.1016/j.jpeds.2016.06.050. https://pubmed.ncbi.nlm.nih.gov/27453368/
26. Long-Term Outcome of Catheter-Related Arterial Thrombosis in Infants with Congenital Heart Disease.
    Rizzi M, Kroiss S, Kretschmar O, Forster I, Brotschi B, Albisetti M.
    J Pediatr. 2016 Mar;170:181-7.e1. doi: 10.1016/j.jpeds.2015.11.024. https://pubmed.ncbi.nlm.nih.gov/26685072/
27. The Morbidity and Mortality Conference in Pediatric Intensive Care as a Means for Improving Patient Safety.
    Frey B, Doell C, Klauwer D, Cannizzaro V, Bernet V, Maguire C, Brotschi B.
    Pediatr Crit Care Med. 2016 Jan;17(1):67-72. doi: 10.1097/PCC.0000000000000550. https://pubmed.ncbi.nlm.nih.gov/26492061/
28. Postoperative Hyperglycemia and 4-Year Neurodevelopmental Outcome in Children Operated for Congenital Heart Disease.
    Krueger JJ, Brotschi B, Balmer C, Bernet V, Latal B.
    J Pediatr. 2015 Dec;167(6):1253-8.e1. doi: 10.1016/j.jpeds.2015.07.007. https://pubmed.ncbi.nlm.nih.gov/26235664/
29. Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register.
    Grass B, Weibel L, Hagmann C, Brotschi B; National Asphyxia and Cooling Register Group.
    BMC Pediatr. 2015 Jul 9;15:73. doi: 10.1186/s12887-015-0395-7. https://pubmed.ncbi.nlm.nih.gov/26156857/
30. The impact of a register on the management of neonatal cooling in Switzerland.
    Brotschi B, Grass B, Ramos G, Beck I, Held U, Hagmann C; National Asphyxia Cooling Register Group; Meyer P, Zeilinger G, Schulzke SM, Wellmann S, Wagner B, Daetwyler K, Nelle M, Bär W, Scharrer B, Tolsa JF, Truttmann A, Schneider J, Pfister RE, Berger TM, Fontana M, Micallef JP, Birkenmayer A, Bucher HU, Natalucci G, Adams M, Frey B, Bernet V, Latal B.
    Early Hum Dev. 2015 Apr;91(4):277-84. doi: 10.1016/j.earlhumdev.2015.02.009. https://pubmed.ncbi.nlm.nih.gov/25768887/
31. Incidence and predictors of cardiac catheterisation-related arterial thrombosis in children.
    Brotschi B, Hug MI, Kretschmar O, Rizzi M, Albisetti M.
    Heart. 2015 Jun;101(12):948-53. doi: 10.1136/heartjnl-2014-306713. https://pubmed.ncbi.nlm.nih.gov/25616691/
32. Gastric pH and residual volume after 1 and 2 h fasting time for clear fluids in children.
    Schmidt AR, Buehler P, Seglias L, Stark T, Brotschi B, Renner T, Sabandal C, Klaghofer R, Weiss M, Schmitz A.
    Br J Anaesth. 2015 Mar;114(3):477-82. doi: 10.1093/bja/aeu399. https://pubmed.ncbi.nlm.nih.gov/25501720/
33. Does amplitude-integrated electroencephalogram background pattern correlate with cerebral injury in neonates with hypoxic-ischaemic encephalopathy?
    Padden B, Scheer I, Brotschi B, Wohlrab G, Latal B, Bernet V.
    J Paediatr Child Health. 2015 Feb;51(2):180-5. doi: 10.1111/jpc.12697. https://pubmed.ncbi.nlm.nih.gov/25123158/
34. Feasibility and safety of passive cooling in a cohort of asphyxiated newborn infants.
    Daetwyler K, Brotschi B, Berger TM, Wagner BP.
    Swiss Med Wkly. 2013 Mar 5;143:w13767. doi: 10.4414/smw.2013.13767. https://pubmed.ncbi.nlm.nih.gov/23519526/
35. Long-term neurodevelopmental outcome with hypoxic-ischemic encephalopathy.
    Perez A, Ritter S, Brotschi B, Werner H, Caflisch J, Martin E, Latal B.
    J Pediatr. 2013 Aug;163(2):454-9. doi: 10.1016/j.jpeds.2013.02.003. https://pubmed.ncbi.nlm.nih.gov/23498155/
36. Therapeutic hypothermia in term infants after perinatal encephalopathy: the last 5 years in Switzerland.
    Ramos G, Brotschi B, Latal B, Bernet V, Wagner B, Hagmann C; Swiss Neonatal Network.
    Early Hum Dev. 2013 Mar;89(3):159-64. doi: 10.1016/j.earlhumdev.2012.09.021. https://pubmed.ncbi.nlm.nih.gov/23116611/
37. Intermittent flushing improves cannula patency compared to continuous infusion for peripherally inserted venous catheters in newborns: results from a prospective observational study.
    Perez A, Feuz I, Brotschi B, Bernet V.
    J Perinat Med. 2012 Jan 19;40(3):311-4. doi: 10.1515/jpm-2011-1000. https://pubmed.ncbi.nlm.nih.gov/22505510
38. In-line filter included into the syringe infusion pump assembly reduces flow irregularities.
    Brotschi B, Grass B, Weiss M, Doell C, Bernet V.
    Intensive Care Med. 2012 Mar;38(3):518-22. doi: 10.1007/s00134-011-2452-5. https://pubmed.ncbi.nlm.nih.gov/22237747/
39. Incidence and predictors of indwelling arterial catheter-related thrombosis in children.
    Brotschi B, Hug MI, Latal B, Neuhaus D, Buerki C, Kroiss S, Spoerri C, Albisetti M.
    J Thromb Haemost. 2011 Jun;9(6):1157-62. doi: 10.1111/j.1538-7836.2011.04271.x. https://pubmed.ncbi.nlm.nih.gov/21449925/
40. Hypothermia for perinatal asphyxial encephalopathy.
    Hagmann CF, Brotschi B, Bernet V, Latal B, Berger TM, Robertson NJ.
    Swiss Med Wkly. 2011 Feb 16;141:w13145. doi: 10.4414/smw.2011.13145. https://pubmed.ncbi.nlm.nih.gov/21328098/
41. Transsphenoidal extension of heterotopic glioneuronal tissue: pathoanatomic considerations in symptomatic neonates.
    Kau T, Gysin C, Dohmen-Scheufler H, Brotschi B, Schiegl H, Kellenberger CJ, Boltshauser E, Scheer I.
    Childs Nerv Syst. 2011 May;27(5):771-8. doi: 10.1007/s00381-010-1326-4. https://pubmed.ncbi.nlm.nih.gov/21057953/
42. Early enteral feeding in conservatively managed stage II necrotizing enterocolitis is associated with a reduced risk of catheter-related sepsis.
    Brotschi B, Baenziger O, Frey B, Bucher HU, Ersch J.
    J Perinat Med. 2009;37(6):701-5. doi: 10.1515/JPM.2009.129. https://pubmed.ncbi.nlm.nih.gov/19678734/

    Originalarbeiten mit Consortium-Autorenschaft

43. COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children.
    Blanchard-Rohner G, Sanchez C, Andre MC, Bressieux-Degueldre S, Grazioli S, Perez MH, Wütz D, Schöbi N, Welzel T, Atkinson A, Schlapbach LJ, Bielicki JA, Trück J;
    Swissped RECOVERY Trial Group. Pediatr Infect Dis J. 2024 Apr 1;43(4):361-364. doi: 10.1097/INF.0000000000004206. https://pubmed.ncbi.nlm.nih.gov/38241661/
44. Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trial.
    Andre MC, Sanchez C, Bressieux-Degueldre S, Perez MH, Wütz D, Blanchard-Rohner G, Grazioli S, Schöbi N, Trück J, Welzel T, Atkinson A, Schlapbach LJ, Bielicki J;
    Swissped RECOVERY Trial Group. EClinicalMedicine. 2023 Dec 6;67:102358. doi: 10.1016/j.eclinm.2023.102358. https://pubmed.ncbi.nlm.nih.gov/38107550/
45. Comparison of clinical characteristics and healthcare resource use of pediatric chronic and non-chronic critically ill patients in intensive care units: a retrospective national registry study.
    Grandjean C, Perez MH, Ramelet AS; OCToPuS Consortium.
    Front Pediatr. 2023 Jun 26;11:1194833. doi: 10.3389/fped.2023.1194833. https://pubmed.ncbi.nlm.nih.gov/37435169/
46. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study.
    Channon-Wells S, Vito O, McArdle AJ, Seaby EG, Patel H, Shah P, Pazukhina E, Wilson C, Broderick C, D’Souza G, Keren I, Nijman RG, Tremoulet A, Munblit D, Ulloa-Gutierrez R, Carter MJ, Ramnarayan P, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Blyuss O, Levin M; Best Available Treatment Study (BATS) consortium.
    Lancet Rheumatol. 2023 Apr;5(4):e184-e199. doi: 10.1016/S2665-9913(23)00029-2. https://pubmed.ncbi.nlm.nih.gov/36855438/
47. Born into an isolating world: family-centred care for babies born to mothers with COVID-19.
    Dowse G, Perkins EJ, Stein HM, Chidini G, Danhaive O, Elsayed YN, Carvalho WB, AlNaqeeb N, Rooze S, Cetinkaya M, Vetter-Laracy S, Pilar-Orive FJ, Torpiano P, Gonçalves Ferri WA, Buonsenso D, Rogdo B, Medina A, Polito A, Brouwer CNM, Kneyber MCJ, De Luca D, Tingay DG; ESPNIC COVID-19 Paediatric and Neonatal (EPICENTRE) Registry.
    EClinicalMedicine. 2023 Feb;56:101822. doi: 10.1016/j.eclinm.2022.101822. https://pubmed.ncbi.nlm.nih.gov/36846297/
48. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial.
    Welzel T, Atkinson A, Schöbi N, Andre MC, Bailey DGN, Blanchard-Rohner G, Buettcher M, Grazioli S, Koehler H, Perez MH, Trück J, Vanoni F, Zimmermann P, Sanchez C, Bielicki JA, Schlapbach LJ; Swissped RECOVERY Trial Group.
    Lancet Child Adolesc Health. 2023 Apr;7(4):238-248. doi: 10.1016/S2352-4642(23)00020-2. https://pubmed.ncbi.nlm.nih.gov/36746174/
49. Sources of Stress, Family Functioning, and Needs of Families With a Chronic Critically Ill Child: A Qualitative Study.
    Grandjean C, Ullmann P, Marston M, Maitre MC, Perez MH, Ramelet AS; OCToPuS Consortium.
    Front Pediatr. 2021 Nov 4;9:740598. doi: 10.3389/fped.2021.740598. https://pubmed.ncbi.nlm.nih.gov/34805041/
50. Treatment of Multisystem Inflammatory Syndrome in Children.
    McArdle AJ, Vito O, Patel H, Seaby EG, Shah P, Wilson C, Broderick C, Nijman R, Tremoulet AH, Munblit D, Ulloa-Gutierrez R, Carter MJ, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Levin M; BATS Consortium.
    N Engl J Med. 2021 Jul 1;385(1):11-22. doi: 10.1056/NEJMoa2102968. https://pubmed.ncbi.nlm.nih.gov/34133854/

Übersichtsarbeiten

1. Intranodale, aszendierende Lymphsklerosierung als minimalinvasive Therapieoption.
   Saager Marie Charlotte, Grotzer Michael, Brotschi Barbara, Kühlwein Eva, Kellenberger Christian, Luhmann-Lunt Carolyn, Gnannt Ralph.
   Swiss Medical Forum. 2022/09-10
2. Empfehlungen der IGPNI zum Temperaturmanagement von pädiatrischen Patienten mit Hirnschädigungen auf der Intensivstation.
   Brotschi B, Kelly J, Rogdo B, Stocker M, Riedel T, Humpel T, Hammer J, Rimensberger P, Perez M-H, Frey B.
   Paediatrica 2020; Volumen 31 Nummer 1, 29-32

Projektarbeit

1. Finanzielle Folgen der Abweisung intensivpflichtiger Patienten für das Universitätskinderspital Zürich in den Jahren 2018/19.
   Brotschi B.
   Im Rahmen des Studienganges CAS Medical Leadership 2020-2021 der UZH